Monomorphic epitheliotropic intestinal tcell lymphoma. Monomorphic adenoma is a rare benign salivary gland epithelial tumor representing monomorphic adenoma. A common histogenesis of the two entities is also suggested. We report ct and mr findings of three cases with basal cell adenoma occurring in the parotid gland. The patient was 36yearold male presenting with an ovoid. Canalicular adenoma and basal cell adenoma were once considered to be a type of monomorphic adenoma. Carcinoma arising in monomorphic adenoma of the salivary gland. Pdf carcinoma ex pleomorphic adenoma of the palate a case. Monomorphic adenoma definition of monomorphic adenoma by. Here we are presenting a case of giant pleomorphic adenoma of the parotid, being the largest in size to be excised in pakistan in. A 48 yearold female patient was admitted to our clinic, who suffered from asymptomatic right preauricular mass lesion for about 8 months.
Multiple primary pleomorphic adenomas in a single parotid gland. Monomorphic adenoma of basal cell type is a salivary gland tumor believed to result from a proliferation of a single type of cell. The patient was a 59yearold japanese man who visited our department in december 2012 with a chief complaint of a mass in the upper lip, which had increased in size over several years. Reed, wid eleven cases of monomorphic adenoma of the salivary glands are interpreted as variants of pleomorphic adenomas mixed tumors that lack chondroid or. We report a case of monomorphic adenoma of aryepiglottic fold. The prognosis of pleomorphic adenoma of salivary gland is generally excellent with surgical intervention and complete removal, since it is a benign tumor however, some tumors are known to recur and recurrent tumors may be disseminated across the oral cavity affecting adjoining structuresregions. Monomorphic definition of monomorphic by the free dictionary.
Selected problems in fine needle aspiration of head and. The three cases presented here demonstrate a wellcircumscribed tumor, which showed a cystic and solid, or the pure solid mass. In addition to carcinoma expleomorphic adenoma, true malignant mixed tumors of the salivary glands usually arise from preexisting pleomorphic adenomas 1,3. It is found mostly in the parotid gland in middleaged women. Pleomorphic adenoma papillary cystadenoma lymphomatosum adenoid cystic carcinoma acinic cell adenocarcinoma mucoepidermoid carcinoma, low grade polymorphous lowgrade adenocarcinoma monomorphic adenoma gingival cyst of adult lymphoepithelial cyst epidermoiddermoid cyst thyroglossal tract cyst squamous cell carcinoma verrucous carcinoma. The cytologic appearance of two rare monomorphic variants of pleomorphic adenomas is described.
Bds,ii and chengchung lin, bdsn three cases of monomorphic basal cell adenoma of the parotid glands were studied with light mi. Monomorphous definition of monomorphous by the free dictionary. Monomorphic adenomas of the major and minor salivary. Monomorphic epitheliotropic intestinal tcell lymphoma meitl was diagnosed. Pleomorphic adenoma has a tendency to continuously grow, and has the potential of becoming cancerous. Monomorphic adenomas are defined as epithelial benign tumors of the salivary glands, which are not pleomorphic adenomas. Though much less likely to occur than pleomorphic adenoma, warthins tumor is the second most common benign parotid tumor. However, there is evidence to support the more conservative approach of. Pleomorphic adenoma benign mixed tumour of the salivary glands. However, ultrastructural and immunocytochemical investigations of 6 monomorphic adenomas 5 from parotid and 1 from intraoral minor salivary gland indicate that there. Only pleomorphic adenoma is a more common benign parotid tumor. In this article, we report the tenth such case, which occurred in an 87yearold japanese woman. A case of adenoid cystic carcinoma was underdiagnosed as basal cell adenoma in fnac.
Panorama of pleomorphic adenoma in a series of patients. Stated differently, knots of cells can be seen joining together two parallel. With the exception of the canalicular adenoma, the basaloid monomorphic adenomas are preponderantly tumors of the major salivary glands, most often the parotid gland. Ce 110 a guide to clinical differential diagnosis of. Pdf fineneedle aspiration cytology of monomorphic adenomas. Warthins tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers lymph nodelike stroma. A clinicopathologic study of a pleomorphic adenoma of the breast is presented and attention is drawn to a previously unreported association with a cyst. These uncommon to rare neoplasms have a predilection for the parotid glands, are diagnosed about a decade later than their benign precursors, and most often arise from the dermal analogue type of monomorphic adenoma.
Basaloid monomorphic adenomas md anderson cancer center. Mri through the left parotid gland demonstrates a sharply circumscribed solid mass in the superficial aspect of the gland. Warthins tumor is slow growing, painless, and primarily affects older individuals. Ct and mr findings mijung jang, dongwoo park, seung ro lee, chang kok hahm, youngsun kim, yongsoo kim, choong ki park, kyung tae, moon hyang park, and yong wook park summary. Uncommon subtype of basal cell monomorphic adenoma with clinical and histological resemblance to dermal cylindroma. Monomorphic adenomas of the major and minor salivary glands. We present a rare case of basal cell adenoma arising in the minor salivary gland of the upper lip. The dermal analogue monomorphic adenomas, so named because of their histologic similarity to eccrine. Adenoma monomorphic picture collection check our collection. In the early stages a pleomorphic adenoma is usually painless but as they start to grow larger these tumors can start to cause complication in your ears or mouth. Pleomorphic adenoma an overview sciencedirect topics. Health, general adenoma case studies cancer research mouth cancer parotid glands physiological aspects. The trabeculartubular adenoma consisted of a trabecular. Benign epithelial tumor comprised of a relatively uniform, monomorphous proliferation of basaloid cells not cell originonly phenotype both duct luminal and myoepithelial cells present dont use monomorphic adenoma.
Monomorphic rash on the neck photo quiz american family. Basal cell adenoma is a specific type of monomorphic tumor of the salivary glands that closely resembles basal cell lesions of the skin. Pleomorphic adenoma is the most common salivary gland tumor in both children and adults. Malignancy was strongly suspected in the light of radiologic features. Adenoma adalah tumor jinak yang dimulai dalam selsel mirip kelenjar dari jaringan epitel, yakni lapisan tipis dari jaringan yang meliputi kulit, organorgan, kelenjar, dan struktur lainnya dalam tubuh. Pleomorphic adenoma is the most common salivary gland tumor for. Monomorphous definition of monomorphous by medical. It is our opinion, as well as that of barnes et al 5 and dardick et al 15 that salivary adenomas are part of a spectrum, with monomorphic adenoma and myoepithelioma at the extremes and a wide range of pleomorphic adenomas in between, depending on the type and degree of gene expression that is coupled with neoplastic transformation. Monomorphous definition of monomorphous by medical dictionary.
The gland most likely affected is the parotid gland. Cyclophosphamide, doxorubicin, vincristine, and prednisone chop and 3 cycles of ifosfamide, carboplatin, and etoposide ice chemotherapy resulted in complete remission cr. Monomorphic adenoma is a rare benign salivary gland epithelial tumor representing adenoma 1. Although the pleomorphic adenoma is normally benign it does have the potential to become cancerous, also referred to as malignant. One was a basal cell adenoma and the other was a myoepithelioma. We represent basal cell adenoma of the parotid gland which was located on the deep lobe of the gland with unusual location the tumor was excised successfully without total parotidectomy. Pleomorphic adenoma is seen more often in females than in males 2. Adenoma juga dapat dikatakan sebagai tumor tetapi tidak mencapai kanker karena pertumbuhannya yang cukup lambat. Newer vesicles continue to appear in monomorphic crops for about one week. This is the first case, to our knowledge, of a monomorphic adenoma presenting at aryepiglottic fold. Pleomorphic adenoma is the most common salivary gland tumor and accounts for approximately 80% of parotid tumors. Warthins tumor is highly unlikely to become malignant. The canalicular adenoma also had a distinctive cyto logic appearance consisting of papillae and interconnected can aliculi lined by a layer of columnar epithelium. Case western reserve university and university of southern california monomorphic adenomas are benign salivary gland tumors that have a predilection.
The lesions have a central umbilication, but quickly become hemorrhagic. Metastasizing pleomorphic adenoma is the third type of malignant mixed tumor of salivary glands and is the rarest. Adenomas of salivary glands one of the many difficulties of salivary gland surgery is the great variety of neoplasms that can form in the salivary gland tissues, and confusion has been caused by the changes in terminology. Monomorphic epitheliotropic intestinal t cell lymphoma meitl formerly termed enteropathyassociated t cell lymphoma, type ii is an extremely rare peripheral tcell lymphoma that involves the malignant proliferation of a type of lymphocyte, the t cell, in the gastrointestinal tract i. It is named for pathologist aldred scott warthin, who described two cases in 1929. Adenoma berasal dari kata adeno yang berarti berkaitan dengan kelenjar. A case of squamous cell carcinoma ex pleomorphic adenoma in a palate is presented and comments on diagnostic criterias are described. Pleomorphic adenoma of the salivary glands radiology. In 1972, who histological classification of salivary gland tumours classified them under other types of monomorphic adenoma. Pleomorphic adenoma is the most common benign salivary gland neoplasm. Materials and methods eleven patients aged 18 years and under were treated atchildrens hospital, bostonfrom 1983 to 2005 for pleomorphic adenoma of the parotid gland. Moreover, with the exception of the canalicular adenoma, all exhibit some degree of myoepithelial cell participation. Differential diagnosis of pleomorphic adenoma by immunohistochemical means volume 105 issue 12 toshiro nishimura, mitsuru furukawa, ei kawahara, atsuo miwa. Monomorphic adenomas are benign salivary gland tumors that have a predilection for development in the upper lip and parotid gland.
Over time, these t cells commonly spread throughout the mucosal lining of a portion of the gi. Monomorphic adenoma is a rare benign salivary gland epithelial tumor representing monomorphic adenomas of the major and minor salivary glands. Basal cell adenomas do not usually show a canalicular pattern of. Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell. Pleomorphic adenomas are benign and tend to increase in size slowly. In 1970 rauch and colleagues classified benign salivary gland neoplasms into two broad categories, monomorphic and pleomorphic adenoma. Uncommon subtype of basal cell monomorphic adenoma with clinical and histological resemblance to dermal cylindroma first described in 1974 by drut and in 1977 by headington and reingold cancer 1977. A clinicopathological analysis of eight examples of carcinomas arising from salivary gland monomorphic adenomas, carcinomas ex monomorphic adenoma, is presented. Complete excision of the mass was done through laryngofissure approach. Statistical data included by ear, nose and throat journal. Primary pulmonary pleomorphic adenoma is a very rare benign tumor that tends to arise in the large airways tumors tend to show small, branching, double layered ductules rather than ducts and less cartilaginous stroma as compared to pleomorphic adenomas arising in the salivary gland. Monomorphic adenomas of the parotid glands their ultrastructure and histogenesis anand p. Recurrent pleomorphic adenoma of submandibular region. Myoepithelial cellrich pleormorphic adenoma of minor.
Monomorphic epitheliotropic intestinal t cell lymphoma. It progresses slowly and, left untreated, can produce signi. In fact, it is the only tumor virtually restricted to the parotid gland. Adenoma wikipedia bahasa indonesia, ensiklopedia bebas.
Monomorphic adenomas can be divided into basaloid and nonbasaloid types. Fine needle aspiration of an unusual malignant mixed tumor in the. Recurrent pleomorphic adenoma of submandibular region aydin s1, demir mg2, akbulut s1, alt. Basal cell adenoma is a rare benign salivary gland epithelial tumor, usually involving the parotid gland. Warthins tumor is a type of benign tumor of the salivary glands, and the gland most likely affected is the parotid gland. Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous glandular cells along with myoepithelial components, having a malignant potentiality. On the 1 year followup there is no recurrence or complaint detected. Carcinomas ex monomorphic adenoma of salivary glands the. Adenoma is a benign epithelial tumor in which the cells from recognisable granular structures or in which the cells are derived from glandular epithelium 3. Monomorphic adenoma article about monomorphic adenoma by. Salivary glands primary salivary gland neoplasms benign canalicular adenoma. Pleomorphic adenoma symptoms, causes, treatment, surgery.
However, ultrastructural and immunocytochemical investigations of 6 monomorphic adenomas 5 from parotid and 1 from intraoral minor salivary gland indicate that there are two classes of these lesions, one composed of two types of tumor cells and the. Chemistry having only one form, as one crystal form. Pleomorphic adenoma of the parotid gland in children. Atlas of head and neck pathology warthins tumor table of contents previous next warthins tumor papillary cystadenoma lymphomatosum adenolymphoma this tumor, seen predominantly in men, generally affects the parotid gland, sometimes bilaterally. Salivary gland tumours are a relatively rare entity. Immunohistochemistry stresses the similarity between pleomorphic adenoma of salivary gland and breast. Adenoma monomorphic picture collection check our collection of adenoma monomorphic pictures and latest news read it at. Distinct monomorphic adenoma with bilayered strands or ribbons of columnar cells with pure luminal ductal epithelial differentiation and loose.
Monomorphic adenoma of basal cell type is a salivary gland tumor believed to result. Around 7080 percent of pleomorphic adenoma occur in the superficial lobe of the parotid gland, although the lesion may occur in any area of the parotid gland. Case western reserve university and university of southern california monomorphic adenomas are benign salivary gland tumors that have a. Multiple primary pleomorphic adenomas in a single parotid. Aryepiglottic fold as a rare location for a monomorphic. Tumors of the minor salivary glands are responsible for 24% of tumors of the head and neck, 10% of tumors of the oral cavity, and 1523% of tumors of the salivary glands. The pathology and surgery of the salivary glands r.
Pleomorphic adenoma is the most common amongst these, comprising 60 70% of all parotid tumours. The development of multiple primary pleomorphic adenomas in a single parotid gland is extremely rare in previously untreated patients, as only nine cases have been previously reported. Fineneedle aspiration cytology of monomorphic adenomas. Pleomorphic adenoma, or benign mixed tumor, is the most common tumor of the parotid gland and represents 70% of all parotid neoplasms. Of these, the basal cell adenoma is the most common. Pathologic examination of the biopsy specimens revealed a diffuse monomorphous population of small and mediumsize lymphocytes with round to oval nuclei, prominent basophilic nucleoli, coarse chromatin, and a thick nuclear membrane. Basal cell adenoma is a rare type of benign salivary gland tumor found most commonly in the parotid gland. Imaging characteristics of recurrent pleomorphic adenoma of.
Aspiration findings were similar in both cases, demonstrating aggregates of mildly disorganised small regular epithelial cells bordered by a thick rim of basement membrane material. Lutfi kirdar kartal education and research hospital, ent department, istanbul, turkey. Get a printable copy pdf file of the complete article 7. Monomorphic adenoma is a rare benign salivary gland epithelial tumor representing monomorphic adenoma, dermal analogue type, are presented illustrating fine. Pleomorphic adenoma is a benign tumor in the salivary gland. The dermal analogue monomorphic adenomas, so named because of their histologic similarity to eccrine tumors of the skin, are a unique subset of the basaloid adenomas. Immune reactive for p63 and high molecular weight cytokeratin.
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